Hi The below code is working
DataTable dtMytable = new DataTable();
dtMytable.Columns.Add("Title");
dtMytable.Columns.Add("Description");
dtMytable.Columns.Add("Weightage");
DataRow dr = dtMytable.NewRow();
dtMytable.Rows.Add(dr);
MyGrid.Visible = true;
MyGrid.DataSource = dtMytable;
MyGrid.DataBind();