sql query to update multiple columns of a single table in one transaction

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i have a table name "table1" and column name "amount" , "2001", "2002","2003","2004"
there are 15000 records in the table.
i have a float value in column "amount"
i have to update 2001 as ( 2001 = amount *10/100)
2002 as ( 2002 = amount *15/100)
2003 as ( 2001 = amount *20/100)
2004 as ( 2001 = amount *22/100)



what should be the code to update all these columns in a single transaction. when i use the following code, i can update only one column not 4 columns

update "table1"
set 2001 as ( 2001 = amount *10/100)

plz help.