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Is it possible to disable the "Automatically Detect Settings" Proxy settings without making modifications to the registry. I know it will make the change to the registry, but curious if I can invoke a method or function or call an API to make the change.
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Hope this[^]will give you an idea.
 
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Use WinHttpGetIEProxyConfigForCurrentUser [^] API to get/set the value.

For C#/VB see this P-Invoke[^]
 
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