You can get it in keydown event.
Private Sub Form1_KeyDown(ByVal sender As Object, ByVal e As System.Windows.Forms.KeyEventArgs) Handles Me.KeyDown
If e.KeyCode = Keys.N And e.Control Then
MessageBox.Show("Ctrl+N is pressed", "Access Keys")
End If
End Sub
For empty form this code is OK, but in form with controls, don't forget to set KeyPreview property of form to true.
KeyPreview = True