WPF

<DataGridTemplateColumn x:Name="..." Header="...">
<DataGridTemplateColumn.CellTemplate>
  <DataTemplate>
    <TextBlock Text="{Binding Path=City}" Style="..."/>
  </DataTemplate>
</DataGridTemplateColumn.CellTemplate>
                                        <DataGridTemplateColumn.CellEditingTemplate>
  <DataTemplate>
    <ComboBox ... />
  </DataTemplate>
</DataGridTemplateColumn.CellEditingTemplate>
</DataGridTemplateColumn>

<Window.CommandBindings>
        <CommandBinding Command="{x:Static my:MainWindow.CustomRoutedCommand}"
                    Executed="ExecutedCustomCommand"
                    CanExecute="CanExecuteCustomCommand" />
</Window.CommandBindings>

Public Shared CustomRoutedCommand As New RoutedCommand()

Private Sub Window_Loaded(ByVal sender As System.Object, ByVal e As System.Windows.RoutedEventArgs) Handles MyBase.Loaded

   'Initialize hotkeys
   Dim customCommandBinding As New CommandBinding(CustomRoutedCommand, AddressOf ExecutedCustomCommand)
   Dim saveKeyGesture As New KeyGesture(Key.F1)
   CustomRoutedCommand.InputGestures.Add(saveKeyGesture)

End Sub

Public Sub ExecutedCustomCommand(ByVal sender As Object, ByVal e As ExecutedRoutedEventArgs)

        If (Keyboard.GetKeyStates(Key.F1) = KeyStates.Down) Then 
            SaveRecord()
        End If

End Sub

<data:DataGridTextColumn
       Header="Employee ID"
       Binding={"Binding EmployeeId"}>
<data:DataGridTextColumn
       Header="Job Name"
       Binding="{Binding EmployeeJobId, Converter={StaticResource JobIdToJobNameConverter}}">

public class JobIdToJobNameConverter : IValueConverter
{
    public object Convert
        (object value,
         Type targetType,
         object parameter,
         CultureInfo culture)
    {
        Job job = JobsProvider.GetJobs().FirstOrDefault
                      (p => p.JobId.Equals ((int) value));
        return job == null ? string.Empty : job.JobName;
    }

    public object ConvertBack
        (object value,
         Type targetType,
         object parameter,
         CultureInfo culture)
    {
        return DependencyProperty.UnsetValue;
    }
}