The calendar can use JSON data, so you can get calendar events from your database for displaying on load, and convert to JSON to send to a method that will save
http://stackoverflow.com/questions/6680878/how-to-retrieve-info-from-database-using-ajax-json-jquery-week-calendar[
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You have an eventNew event that occurs whenever you add a new item to the calendar, you can write a handler to for this + send the data to some sort of service that will perform the database operation.
If you're writing in ASP.Net Webforms, a web service will probably be the easiest way to achieve this