Hi,
You can call a javacript function in
"onchage" of the 2nd dropdown.
First of all register both the dropdowns with hidden fields in the page load like
Page.RegisterHiddenField("hidden field name", dropdownid.ClientID);
Then in the javascript, get the value of both the dropdowns like
document.getElementById(document.getElementById("hiddenfieldname").value).value
Then check appropriately as you want, like
if(value of 1st dropdwn < value of 2nd drop down), show a message like
Alert("Your message")
Happy Coding :)