Run a query selecting the rows or COUNT where the email is the same as the input email.
E.g.
SqlCommand command = new SqlCommand("SELECT COUNT(*) FROM users u WHERE u.email = :EMAIL", myConnection);
command.Parameters.Add(":EMAIL", SqlDbType.VarChar).Value = inputEmail;
int count = (int) command.ExecuteScalar();
if(count != 0)
{
}