What you exactly want to do;
To make panel non-responsive, such that it is visible to user but user can't able to click on any buttons. Normally, this is possible by enable/disable.
And if you want them to be make non available for users, then simple make it invisible.
Add this panel to separate div in html. And then simply, make this div "visible/invisible" or "enable/disable".
And if you want to disable panel directly, then go for;
To make disable;
var panel = document.getElementById('<%=PanelID.ClientID%>');
panel.enable=false
or
To make invisible
var panel = document.getElementById('<%=PanelID.ClientID%>');
panel.visible=false
For both cases, it is necessary to add
ClientIDMode="Static"
property to panel tag at html side.