Although its not clear what are you trying to express, but here are some tips that might help you. If you want the action to be taken on the server side, at the time when you are binding the dropdown, you can add/attach the event to the dropdown & set the dropdown property AutoPostBack to true.
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DropDownList.AutoPostBack = True
AddHandler DropDownList.SelectedIndexChanged, AddressOf DropDownList_SelectedIndexChanged
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Protected Sub DropDownList_SelectedIndexChanged(ByVal sender As Object, ByVal e As System.EventArgs)
.. your code ..
End Sub
If you want the action to be taken on client side, at the time when you are binding the dropdown, use the attribute "onchange" property of the dropdown to add the client side script.
DropDownList.Attributes("OnChange") = "javascript: doSomething();"