TIFF is a graphics file format, so you need to load it, get a context, draw on it, and save the result:
using (Image i = new Bitmap(@"D:\Test data\MyPic.Tif"))
{
using (Graphics g = Graphics.FromImage(i))
{
g.DrawString("Test Text", Font, Brushes.Cyan, 100, 100);
}
i.Save(@"D:\Test data\MyPic.Edit.tif", ImageFormat.Tiff);
}