Read Data from Excel Sheet

using System.Data;
using System.Data.OleDb;

OleDbConnection con = new OleDbConnection(@"Provider=Microsoft.Jet.OLEDB.4.0;Data Source=C:\Book1.xls;Extended Properties=Excel 8.0");
OleDbDataAdapter da = new OleDbDataAdapter("select * from MyObject", con);
DataTable dt = new DataTable();
da.Fill(dt);

Change your Excel sheet into CSV file and try this:

FileUpload1.SaveAs(Server.MapPath("~/tmpdir/") + FileUpload1.FileName);
System.IO.StreamReader myFile = new System.IO.StreamReader(Server.MapPath("~/tmpdir/")    + FileUpload1.FileName);
string myString = myFile.ReadToEnd();
myFile.Close();
string[] lines = myString.Split(new string[] { Environment.NewLine },      StringSplitOptions.None);
 
foreach (string line in lines)
 {
     if (line != "")
      {
          string[] columns = line.Split(',');
 
          //Upload to your DB with your indexes

      }
     else
      {
 
      }
}