C#

<Window x:Class="Samples.MainWindow"
        xmlns="http://schemas.microsoft.com/winfx/2006/xaml/presentation"
        xmlns:x="http://schemas.microsoft.com/winfx/2006/xaml"
        xmlns:vm="clr-namespace:Samples.ViewModel"
        xmlns:i="http://schemas.microsoft.com/expression/2010/interctivity"
        Title="MainWindow" Style="{StaticResource styWindow}">

    <Window.DataContext>
        <vm:LabTechViewModel />
    </Window.DataContext>

    <Window.Resources>
        
        <DataTemplate x:Key="techData">
            <Border Margin="2"
                BorderThickness="2"
                CornerRadius="4"
                BorderBrush="SteelBlue" 
                    HorizontalAlignment="Stretch">
                <Grid ShowGridLines="False" HorizontalAlignment="Stretch">
                    <Grid.ColumnDefinitions>
                        <ColumnDefinition />
                    </Grid.ColumnDefinitions>
                    <Grid.RowDefinitions>
                        <RowDefinition />
                        <RowDefinition />
                    </Grid.RowDefinitions>
                    <TextBlock Grid.Row="0" Text="{Binding TechID}">
                    </TextBlock>
                    <TextBlock Grid.Row="1" Text="{Binding TechName}" FontWeight="Bold">
                    </TextBlock>
                </Grid>
            </Border>
        </DataTemplate>
        
        <DataTemplate x:Key="progBar">
            <Border BorderThickness="2"
                    BorderBrush="Blue"
                    CornerRadius="4"
                    HorizontalAlignment="Stretch">
                <Grid>
                <ProgressBar HorizontalAlignment="Stretch"
                             VerticalAlignment="Stretch"
                             Minimum="{Binding Minimum}"
                             Maximum="{Binding Maximum}"
                             Value="{Binding ProgressValue}"/>
                <Button x:Name="progButton"
                    HorizontalAlignment="Stretch"
                    VerticalAlignment="Stretch"
                    Command="{Binding ProgressCommand}"
                    Content="{Binding ProgressButtonContent, FallbackValue='Bite Me'}"
                    Background="Transparent" />
                </Grid>             
            </Border>
        </DataTemplate>
        
    </Window.Resources>

    <Grid ShowGridLines="True">
        <Grid.ColumnDefinitions>
            <ColumnDefinition Width="*" />
            <ColumnDefinition Width="*" />
            <ColumnDefinition Width="*" />
        </Grid.ColumnDefinitions>
        <Grid.RowDefinitions>
            <RowDefinition />
            <RowDefinition />
        </Grid.RowDefinitions>
        <StackPanel>

            <ComboBox x:Name="lstOperators"
                    HorizontalAlignment="Stretch"
                    HorizontalContentAlignment="Stretch"
                    ItemsSource="{Binding LabTechs}"
                    ItemTemplate="{StaticResource techData}"
                    SelectedItem="{Binding LabTechSelected}"
                    SelectedIndex="0"
                    >
            </ComboBox>
            
            <ContentControl ContentTemplate="{StaticResource progBar}"
                            >
                
            </ContentControl>


        </StackPanel>
    </Grid>
</Window>

//This is the constructor
        public LabTechViewModel()
        {
            _techList = DataAccess.GetAllLabTechs();
            _progressCommand = new RelayCommand(param => this.OnProgressClicked());
        }

        private RelayCommand _progressCommand;
        public ICommand ProgressCommand
        {
            get
            {
                if (_progressCommand == null)
                    _progressCommand = new RelayCommand(param => this.OnProgressClicked());

                return _progressCommand;
            }
        }

        void OnProgressClicked()
        {
            if (_progButtonContent == "Stopped, Click to Start")
            {
                //Start the Comm scan 
                _progButtonContent = "Scanning, click to stop";
                RaisePropertyChanged("ProgressButtonContent");
                RaisePropertyChanged("ProgressMaximum");
                RaisePropertyChanged("ProgerssMinimum");
            }
        }

class RelayCommand : ICommand
{
    readonly Action<object> _execute;
    readonly Predicate<object> _canExecute;

    public RelayCommand(Action<object> execute, Predicate<object> canExecute)
    {
        if (execute == null) throw new ArgumentNullException("execute");

        _execute = execute;
        _canExecute = canExecute;
    }

    public RelayCommand(Action<object> execute) : this(execute, null) { }

    public bool CanExecute(object parameters)
    {
        return _canExecute == null ? true : _canExecute(parameters);
    }

    public event EventHandler CanExecuteChanged
    {
        add { CommandManager.RequerySuggested += value; }
        remove { CommandManager.RequerySuggested -= value; }
    }

    public void Execute(object parameters)
    {
        _execute(parameters);
    }
}

  Dim DesChkBox As New DataGridViewCheckBoxColumn
  DesChkBox.Name = "chbSelect"
  DesChkBox.HeaderText = "Select"
  DesChkBox.TrueValue = True
  DesChkBox.FalseValue = False
  grdView.Columns.Add(DesChkBox)
  DesChkBox.Width = 50
  grdView.ReadOnly = False
  grdView.AutoGenerateColumns = False
  grdView.RowHeadersWidth = 5


And through a procedure I want to check the Check Box programmatically.
Private Sub prcDefaultSelection()
Try
     grdView.Rows(0).Cells(3).Value = True
       Catch ex As Exception
           MsgBox(Err.Description)
       End Try
End Sub

The Check Box is not Checking. Please help me.

public void variance(REngine e, int[] x,int[] y)
        {

            var var1 = e.Evaluate("var").AsFunction();
            var1.Invoke(x,y).AsNumeric();
        }    

The request failed. The underlying connection was closed: Could not establish trust relationship for the SSL/TLS secure channel.

using System.Net;
using System.Net.Mail;
using Microsoft.Exchange.WebServices;
using System.Security.Cryptography;
using System.Security.Cryptography.X509Certificates;

        private void emailNotifyUser ()
        {
Microsoft.Exchange.WebServices.Data.ExchangeService service = new Microsoft.Exchange.WebServices.Data.ExchangeService(Microsoft.Exchange.WebServices.Data.ExchangeVersion.Exchange2010_SP1);
            service.Credentials =
                new Microsoft.Exchange.WebServices.Data.WebCredentials("you@you.com", "password1", "domain.com);
            service.TraceEnabled = true;
            service.TraceFlags = Microsoft.Exchange.WebServices.Data.TraceFlags.All;
            service.Url = new Uri("HTTPS://xxxxxxx/EWS/Exchange.asmx"); // https://xxxxxxx.xxx/autodiscover/autodiscover.xml
            //service.AutodiscoverUrl(To,
            //    RedirectionUrlValidationCallback);
            //ServicePointManager.ServerCertificateValidationCallback = new System.Net.Security.RemoteCertificateValidationCallback
            //(
            //   delegate { return true; }
            //);
            // trust sender
            //System.Net.ServicePointManager.ServerCertificateValidationCallback
            //                = ((sender, cert, chain, errors) => cert.Subject.Contains("nsc-cas-01"));
            ServicePointManager.ServerCertificateValidationCallback += new System.Net.Security.RemoteCertificateValidationCallback(ValidateRemoteCertificate);
            Microsoft.Exchange.WebServices.Data.EmailMessage email = new Microsoft.Exchange.WebServices.Data.EmailMessage(service);
            email.ToRecipients.Add(To);
            email.Subject = "HelloWorld";
            email.Body = new Microsoft.Exchange.WebServices.Data.MessageBody("First email using EWS Managed API");
            email.Body.BodyType = Microsoft.Exchange.WebServices.Data.BodyType.HTML;
            email.Send();
}

private static bool ValidateRemoteCertificate(object sender, X509Certificate cert, X509Chain chain, System.Net.Security.SslPolicyErrors policyErrors)
{
    bool result = false;
    if (cert.Subject.ToUpper().Contains("cas-server-name"))
    {
        result = true;
    }

    return result;
}