C#

public Form1()
        {
            InitializeComponent();

            AutoScrollMinSize = new Size(1000, 1000);
            SetStyle(
                ControlStyles.AllPaintingInWmPaint | 
                ControlStyles.UserPaint | 
                ControlStyles.OptimizedDoubleBuffer, true);
            UpdateStyles();
        }

        protected override void OnPaint(PaintEventArgs e)
        {
            base.OnPaint(e);
            e.Graphics.FillRectangle(Brushes.Red, new Rectangle(0, 0, 30, 30));
        }

        protected override void OnScroll(ScrollEventArgs se)
        {
            Invalidate();
            base.OnScroll(se);
        }

        protected override void OnMouseWheel(MouseEventArgs e)
        {
            Invalidate();
            base.OnMouseWheel(e);
        }