Well, you need to know what registers/coils you need to read - that is, what MODBUS functions, and the register/coil addresses you need to get data from - If you're using the .Net serial port implementation you're already up sh*t creek unfortunately, its DataReceived event may or may not play well with your device on the other end of the serial cable
There's a project set up here
Simple Modbus Protocol in C# / .NET 2.0[
^] that may help you get started, and a MODBUS protocol manual here
http://modbus.org/docs/PI_MBUS_300.pdf[
^] that may be useful
since as OG points out, you havnt told us what information/help you need and/or what MODBUS device you're using, thats about as much as one can offer you by way of help
[edit]
this
GitHub - NModbus4/NModbus4: NModbus4 is a C# implementation of the Modbus protocol.[
^] may also help
[/edit]