If you want the values which are in both lists:
var inBoth = firstList.Intersect(secondList);
If you want the values which are in the first list, but not the second:
var inFirst = firstList.Except(secondList);
If you want the values which are not common to both lists:
var notInBoth = firstList.Except(secondList).Union(secondList.Except(firstList));