<asp:dropdownlist id="dropDown" runat="server" autopostback="true" onselectedindexchanged="dropDown_SelectedIndexChanged" xmlns:asp="#unknown">
<asp:listitem text="Select" value="0" selected="True"></asp:listitem>
<asp:listitem text="Item 1" value="1"></asp:listitem>
<asp:listitem text="Item 2" value="2"></asp:listitem>
</asp:dropdownlist>
protected void dropDown_SelectedIndexChanged(object sender, EventArgs e)
{
if (dropDown.SelectedValue != "0")
{
}
}