Try as below code.
DataSet mydata = new DataSet("mydata");
mydata.ReadXml("YourXmlFilePath");
DataTable firstDataTable = new DataTable();
DataTable secondDataTable = new DataTable();
if (mydata.Tables.Count > 0)
{
firstDataTable = mydata.Tables[0].Copy();
secondDataTable = mydata.Tables[0].Copy();
firstDataTable.Columns.Remove("ColumnNameToRemove1");
secondDataTable.Columns.Remove("ColumnNameToRemove2");
}