.NET (Core and Framework)

if (System.IO.File.Exists(serpath))
{

    System.Drawing.Image myimage1 = System.Drawing.Image.FromFile(serpath);

    int thumb_width = 400, thumb_height = 100;
    using (System.Drawing.Bitmap thumb_bitmap = new System.Drawing.Bitmap(thumb_width, thumb_height))
    {
        using (System.Drawing.Graphics g = System.Drawing.Graphics.FromImage(thumb_bitmap))
        {
            g.InterpolationMode = System.Drawing.Drawing2D.InterpolationMode.HighQualityBicubic;
            g.Clear(Color.White);
            g.DrawImage(myimage1, 0, 0, thumb_width, thumb_height);
        }
        myimage1.Dispose();
        System.Drawing.Imaging.ImageCodecInfo jpeg = default(System.Drawing.Imaging.ImageCodecInfo);
        jpeg = System.Drawing.Imaging.ImageCodecInfo.GetImageEncoders().
               Where((System.Drawing.Imaging.ImageCodecInfo enc) => 
                   enc.FormatID == System.Drawing.Imaging.ImageFormat.Jpeg.Guid)
                   .FirstOrDefault();


        System.Drawing.Imaging.EncoderParameters Params = new System.Drawing.Imaging.EncoderParameters(1);
        Params.Param[0] = new System.Drawing.Imaging.EncoderParameter(System.Drawing.Imaging.Encoder.Quality, 100L);

        thumb_bitmap.Save(serpath, jpeg, Params);

    }
    
}
else
{
    signatureImage.Save(serpath, System.Drawing.Imaging.ImageFormat.Jpeg);
}
}

private class Signature
{
    public List<List<List<double>>> lines { get; set; }
}

var signature = serializer.Deserialize<Signature>(json);

{
   lines: [
            [
               [156.44, 96.44],
               [156.44, 95.33],
               [155.33, 94.22],
               [154.22, 93.11],
               [154.22, 90.89],
               [153.11, 89.78],
               ...
            ]
   ]
}

private sealed class SignatureLine
{
    public int lx { get; set; }
    public int ly { get; set; }
    public int mx { get; set; }
    public int my { get; set; }
}

private class Signature
{
    public List<List<List<double>>> lines { get; set; }
    
    public IEnumerable<SignatureLine> SignatureLines
    {
        get
        {
            foreach (List<List<double>> stroke in lines)
            {
                if (stroke.Count == 1) continue;
                
                List<double> lastPoint = stroke[0];
                Debug.Assert(lastPoint.Count == 2);
                
                foreach (List<double> point in stroke.Skip(1))
                {
                    Debug.Assert(point.Count == 2);
                    
                    // For now, just round the floating point values to the nearest integer:
                    yield return new SignatureLine
                    {
                        lx = (int)Math.Round(lastPoint[0]),
                        ly = (int)Math.Round(lastPoint[1]),
                        mx = (int)Math.Round(point[0]),
                        my = (int)Math.Round(point[1])
                    };
                    
                    lastPoint = point;
                }
            }
        }
    }
}

...

var serializer = new JavaScriptSerializer();
var signature = serializer.Deserialize<Signature>(json);
foreach (SignatureLine line in signature.SignatureLines)
{
   signatureGraphic.DrawLine(pen, line.lx, line.ly, line.mx, line.my);
}

signatureImage.Save(Server.MapPath("~/images/s1.jpg"), ImageFormat.Jpeg);