Look at the error message:
An unhandled exception of type 'System.IO.DirectoryNotFoundException' occurred in mscorlib.dll Additional information: Could not find a part of the path 'C:\Users\Qsk\Desktop\FINFORM\cortexForm\bin\Debug\lib\cortex\vCom.cortex
It couldn't be a lot clearer!
It is saying that part of the path does not exist: a relative path is relative to the current folder, which is normally the folder the executable you are running it located in.
In order to save (or open) the file, the entire path must be created first, and it must have the correct permissions for the user the application is running under. Check the path, and use the Directory.CreateDirectory method to make it if necessary.