C#

/// Handler for when the mouse moves over the image part of the picture box
public delegate void MouseMoveOverImageHandler(object sender, MouseEventArgs e);

/// Occurs when the mouse have moved over the image part of a picture box
public event MouseMoveOverImageHandler MouseMoveOverImage;

/// Handler for when the mouse clicks over the image part of the picture box
public delegate void MouseClickedImageHandler(object sender, MouseEventArgs e);

/// Occurs when the mouse have clicked over the image part of a picture box
public event MouseMoveOverImageHandler MouseClickedImage;

protected override void OnMouseClick(MouseEventArgs e)
{
    base.OnMouseClick(e);
    if (Image != null)
    {
        if (MouseClickedImage != null)
        {
            Point p = TranslatePointToImageCoordinates(e.Location);
            if (p.X >= 0 && p.X < Image.Width && p.Y >= 0 && p.Y < Image.Height)
            {
                MouseEventArgs ne = new MouseEventArgs(e.Button, e.Clicks, p.X, p.Y, e.Delta);
                MouseClickedImage(this, ne);
            }
        }
    }
}