C#

using System;
using System.Collections.Generic;
using System.ComponentModel;
using System.Data;
using System.Drawing;
using System.Linq;
using System.Text;
using System.Windows.Forms;

namespace paintImage
{
    enum ButtonState
    {
        NotSelected,
        Blue,
        Green

    }
    public partial class Form1 : Form
    {
        ButtonState Language = ButtonState.NotSelected;
        private bool MouseOutLanguageTraining = false;
        private bool LanguageTraining = false;
        private bool MouseOnLangugeTraining = false;
        Rectangle LanguageButtonPosition = new Rectangle(774, 617, 218, 42);
        //private Point MouseClickPosition;
        //private readonly Brush TextBrush = Brushes.White;
        //private readonly Font ButtonFont = new Font("alefba", 18,FontStyle.Bold);
        
        readonly Image piccy;
        readonly Image ButtonSelectedBlue;
        readonly Image ButtonSelectedGreen;
        readonly Image ButtonNotSelected;

        private readonly Point[] piccyBounds;
        private readonly Point[] LanguageButtonBounds;
        public Form1()
        {
            InitializeComponent();
            piccy = Image.FromFile(@"C:\pics\page12.png");
            ButtonNotSelected = Image.FromFile(@"C:\Pics\Button Not Selected.png");
            ButtonSelectedBlue = Image.FromFile(@"C:\pics\Button Selected Blue.png");
            ButtonSelectedGreen = Image.FromFile(@"C:\pics\Button Selected Green.png");
            AutoScrollMinSize = piccy.Size;
            piccyBounds = new Point[3];
            LanguageButtonBounds = new Point[3];
            
            const int resolutionX = 1024; //the x dimension of the display resolution
            const int resolutionY = 768; //the y dimension of the display resolution

           
            piccyBounds[0] = new Point(0, 0);
            piccyBounds[1] = new Point(resolutionX, 0);
            piccyBounds[2] = new Point(0, resolutionY);

            LanguageButtonBounds[0] = new Point(744, 617);
            LanguageButtonBounds[1] = new Point(992, 617);
            LanguageButtonBounds[2] = new Point(744, 659);

        }

        protected override void OnPaint(PaintEventArgs e)
        {


            //this.Show();
            //this.BringToFront();
            Graphics dc = e.Graphics;
            base.OnPaint(e);
            //dc.TranslateTransform(AutoScrollPosition.X, AutoScrollPosition.Y);
            //dc.TranslateTransform(AutoScrollPosition.X, AutoScrollPosition.Y);
            dc.DrawImage(piccy, piccyBounds);

            if (LanguageTraining && (Language != ButtonState.Blue))
            {
                //dc.FillRectangle(Brushes.White, new Rectangle(744, 617, 248, 42));
                dc.DrawImage(ButtonSelectedBlue, LanguageButtonBounds);
                LanguageTraining = false;
                //base.OnPaint(e);
                //return;
            }
            else if (MouseOnLangugeTraining && (Language != ButtonState.Green))
            {
                dc.DrawImage(ButtonSelectedGreen, LanguageButtonBounds);
                MouseOnLangugeTraining = false;
            }
            else if (MouseOutLanguageTraining && (Language != ButtonState.NotSelected))
            {
                dc.DrawImage(ButtonNotSelected, LanguageButtonBounds);
                MouseOutLanguageTraining = false;
            }
            //dc.DrawString("Language Training", ButtonFont, TextBrush, new Point(755, 625));
        }

        protected override void OnKeyUp(KeyEventArgs e)
        {
            base.OnKeyUp(e);
            if (e.KeyCode == Keys.Escape)
                this.Close();
        }
   
        protected override void OnMouseClick(MouseEventArgs e)
        {
            base.OnMouseClick(e);
            Point mouseLocation = Control.MousePosition;
            if (mouseLocation.X > 755 && mouseLocation.X < 992 && mouseLocation.Y > 625 && mouseLocation.Y < 659)
            {
                Invalidate();
                LanguageTraining = true; //means that only language training button should be repainted
            }
        }
        
   
        protected override void OnMouseMove(MouseEventArgs e)
        {
            base.OnMouseMove(e);

            Point mouseLocation = Control.MousePosition;
            if (mouseLocation.X > 755 && mouseLocation.X < 992 && mouseLocation.Y > 625 && mouseLocation.Y < 659)
            {
                MouseOnLangugeTraining = true;
                Invalidate();

            }
            else if (mouseLocation.X < 755 || mouseLocation.X > 992 || mouseLocation.Y < 625 || mouseLocation.Y > 659)
            {
                MouseOutLanguageTraining = true;
                Invalidate(LanguageButtonPosition);
            }
        }
           private void Form1_Load(object sender, EventArgs e)
        {

        }
    }
}

using System.Drawing;
namespace paintImage
{
    partial class Form1
    {
        /// <summary>
        /// Required designer variable.
        /// </summary>
        private System.ComponentModel.IContainer components = null;

        /// <summary>
        /// Clean up any resources being used.
        /// </summary>
        /// <param name="disposing">true if managed resources should be disposed; otherwise, false.</param>
        protected override void Dispose(bool disposing)
        {
            piccy.Dispose();
            ButtonSelectedBlue.Dispose();
            ButtonNotSelected.Dispose();
            ButtonSelectedGreen.Dispose();
            
            //TextZabanSara.Dispose();
            if (disposing && (components != null))
            {
                components.Dispose();
            }
            base.Dispose(disposing);
        }

        #region Windows Form Designer generated code

        /// <summary>
        /// Required method for Designer support - do not modify
        /// the contents of this method with the code editor.
        /// </summary>
        private void InitializeComponent()
        {
            this.SuspendLayout();
            // 
            // Form1
            // 
            this.AutoScaleDimensions = new System.Drawing.SizeF(6F, 13F);
            this.AutoScaleMode = System.Windows.Forms.AutoScaleMode.Font;
            this.BackColor = System.Drawing.Color.Silver;
            this.ClientSize = new System.Drawing.Size(1024, 768);
            this.DoubleBuffered = true;
            this.FormBorderStyle = System.Windows.Forms.FormBorderStyle.None;
            this.Name = "Form1";
            this.StartPosition = System.Windows.Forms.FormStartPosition.Manual;
            this.Text = "Form1";
            this.TransparencyKey = System.Drawing.Color.Transparent;
            this.Load += new System.EventHandler(this.Form1_Load);
            this.ResumeLayout(false);

        }

        #endregion
    }
}

Point start;
		private void pictureBox_MouseDown(object sender, MouseEventArgs e)
		{
			start = e.Location;
		}

		private void pictureBox_MouseMove(object sender, MouseEventArgs e)
		{
			if (e.Button == MouseButtons.Left)
			{
				Size selSize=new Size(e.X - start.X, e.Y - start.Y);
				Rectangle selRect = new Rectangle(start, selSize);
				selRect.Offset(((Control)sender).Location);
				foreach (Control ctl in this.flowLayoutPanel1.Controls)
				{
					if (ctl.Bounds.IntersectsWith(selRect))
					{
						// Here goes your code for doing whatever you need to "select"
						// the picture box...

						ctl.BackColor = Color.Yellow;
					}
					else
					{
						// Here goes your code for doing whatever you need to "deselect"
						// the picture box...

						ctl.BackColor = Color.Gray;
					}
				}
			}
		}